MovDisordV3, Main, Exploration, bibRecord, 003C85

In vivo imaging of microglial activation with [11C](R)‐PK11195 PET in corticobasal degeneration

Identifieur interne : 003C85 ( Main/Exploration ); précédent : 003C84; suivant : 003C86

In vivo imaging of microglial activation with [11C](R)‐PK11195 PET in corticobasal degeneration

Auteurs : Alexander Gerhard [Royaume-Uni] ; Justin Watts [Royaume-Uni, États-Unis] ; Iris Trender-Gerhard [Royaume-Uni] ; Federico Turkheimer [Royaume-Uni] ; Richard B. Banati [Royaume-Uni] ; Kailash Bhatia [Royaume-Uni] ; David J. Brooks [Royaume-Uni]

Source :

Movement Disorders [ 0885-3185 ] ; 2004-10.

RBID : ISTEX:031BA769DE2642A0391D4654EF9922AA7CF66F48

Descripteurs français

Pascal (Inist)
- Dégénérescence, Positon, Système nerveux pathologie, Tomoscintigraphie.

English descriptors

KwdEn :
- Aged, Basal Ganglia (blood supply), Basal Ganglia (pathology), Basal Ganglia (radionuclide imaging), Cerebral Cortex (blood supply), Cerebral Cortex (pathology), Cerebral Cortex (radionuclide imaging), Degeneration, Emission tomography, Female, Humans, Isoquinolines (diagnostic use), Male, Microglia (pathology), Microglia (radionuclide imaging), Middle Aged, Nerve Degeneration (pathology), Nerve Degeneration (radionuclide imaging), Nervous system diseases, Positron, Positron-Emission Tomography, Radiopharmaceuticals (diagnostic use), [11C](R)‐PK11195 PET, activated microglia, corticobasal degeneration.
MESH :
- chemical , diagnostic use : Isoquinolines, Radiopharmaceuticals.
- blood supply : Basal Ganglia, Cerebral Cortex.
- pathology : Basal Ganglia, Cerebral Cortex, Microglia, Nerve Degeneration.
- radionuclide imaging : Basal Ganglia, Cerebral Cortex, Microglia, Nerve Degeneration.
- Aged, Female, Humans, Male, Middle Aged, Positron-Emission Tomography.

Abstract

Corticobasal degeneration (CBD) is a neurodegenerative parkinsonian disorder of unknown cause that shows considerable clinical heterogeneity. In CBD, activated microglia have been shown to be associated closely with the extensive tau pathology found in the affected basal ganglia, brainstem nuclei, and cortical regions. We report on the use of [11C](R)‐(1‐[2‐chlorophenyl]‐N‐methyl‐N‐[1‐methylpropyl]‐3‐isoquinoline carboxamide) (PK11195) positron emission tomography (PET), a marker of peripheral benzodiazepine binding sites (PBBS) that are expressed by activated microglia, to demonstrate in vivo the degree and distribution of glial response to the degenerative process in 4 patients with CBD. Compared with normal age‐matched controls, the CBD patient group showed significantly increased mean [11C](R)‐PK11195 binding in the caudate nucleus, putamen, substantia nigra, pons, pre‐ and postcentral gyrus, and the frontal lobe. [11C](R)‐PK11195 PET reveals a pattern of increased microglial activation in CBD patients involving cortical regions and the basal ganglia that corresponds well with the known distribution of neuropathological changes, which may therefore help to characterize in vivo the underlying disease activity in CBD. © 2004 Movement Disorder Society

Url:

https://api.istex.fr/document/031BA769DE2642A0391D4654EF9922AA7CF66F48/fulltext/pdf

DOI: 10.1002/mds.20162

Affiliations:

Le document en format XML

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<author><name sortKey="Turkheimer, Federico" sort="Turkheimer, Federico" uniqKey="Turkheimer F" first="Federico" last="Turkheimer">Federico Turkheimer</name>
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<term>Basal Ganglia (radionuclide imaging)</term>
<term>Cerebral Cortex (blood supply)</term>
<term>Cerebral Cortex (pathology)</term>
<term>Cerebral Cortex (radionuclide imaging)</term>
<term>Degeneration</term>
<term>Emission tomography</term>
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<term>Nerve Degeneration (radionuclide imaging)</term>
<term>Nervous system diseases</term>
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<term>Radiopharmaceuticals (diagnostic use)</term>
<term>[11C](R)‐PK11195 PET</term>
<term>activated microglia</term>
<term>corticobasal degeneration</term>
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<term>Microglia</term>
<term>Nerve Degeneration</term>
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<front><div type="abstract" xml:lang="en">Corticobasal degeneration (CBD) is a neurodegenerative parkinsonian disorder of unknown cause that shows considerable clinical heterogeneity. In CBD, activated microglia have been shown to be associated closely with the extensive tau pathology found in the affected basal ganglia, brainstem nuclei, and cortical regions. We report on the use of [11C](R)‐(1‐[2‐chlorophenyl]‐N‐methyl‐N‐[1‐methylpropyl]‐3‐isoquinoline carboxamide) (PK11195) positron emission tomography (PET), a marker of peripheral benzodiazepine binding sites (PBBS) that are expressed by activated microglia, to demonstrate in vivo the degree and distribution of glial response to the degenerative process in 4 patients with CBD. Compared with normal age‐matched controls, the CBD patient group showed significantly increased mean [11C](R)‐PK11195 binding in the caudate nucleus, putamen, substantia nigra, pons, pre‐ and postcentral gyrus, and the frontal lobe. [11C](R)‐PK11195 PET reveals a pattern of increased microglial activation in CBD patients involving cortical regions and the basal ganglia that corresponds well with the known distribution of neuropathological changes, which may therefore help to characterize in vivo the underlying disease activity in CBD. © 2004 Movement Disorder Society</div>
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<country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Watts, Justin" sort="Watts, Justin" uniqKey="Watts J" first="Justin" last="Watts">Justin Watts</name>
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Movement Disorders (revue)

In vivo imaging of microglial activation with [11C](R)‐PK11195 PET in corticobasal degeneration

In vivo imaging of microglial activation with [11C](R)‐PK11195 PET in corticobasal degeneration

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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